Season Two
| Emily Watson ... Mother Superior Valya Harkonnen |
| Olivia Williams ... Sister Tula Harkonnen |
| Travis Fimmel ... Desmond Hart |
| Jodhi May ... Empress Natalya Arat Corrino |
| Sarah-Sofie Boussnina ... Princess Ynez Corrino |
| Chloe Lea ... Sister Lila |
| Chris Mason ... Keiran Atreides |
| Shalom Brune-Franklin ... Mikaela |
| Mark Strong ... Emperor Javicco Corrino |
| Jade Anouka ... Sister Theodosia |
| Edward Davis ... Harrow Harkonnen |
| Josh Heuston ... Constantine Corrino |
| Faoileann Cunningham ... Sister Jen |
| Aoife Hinds ... Sister Emeline |
| Mark Addy ... Evgeny Harkonnen |
| Polly Walker ... Sonya Harkonnen |
| Jessica Barden ... Young Valya Harkonnen |
| Emma Canning ... Young Tula Harkonnen |
| Cathy Tyson ... Raquella Berto-Anirul |
| Camilla Beeput ... Reverend Mother Dorotea |
| Barbara Marten ... Sister Avila |
| Yerin Ha ... Young Kasha Jinjo |
| Charithra Chandran ... Young Francesca |
| Earl Cave ... Griffin Harkonnen |
| Milo Callaghan ... Orry Atreides |
