- Ep: 336
- Treehouse of Horror XV
- Blackboard Line: None
- Starring: I Was A Teenaged Dan Castellaneta, Ghouls Kavner, Bartfright Cartwright, Aeeiy Lmrdthys, The Republican Party, Harry Shearer
- Also Starring: Terror MacNihil, Snarl Wiederghost
- Additional Vocals By: Marie Cain
- Written By: Bill Odenkirk
- Directed By: The Tell-Tale Silverman
- Ep: 337
- All's Fair in Oven War
- Blackboard Line:
- Special Guest Voices: James Caan, Thomas Pynchon, Marcia Wallace
- Also Starring: Pamela Hayden, Tress MacNeille, Karl Wiedergott
- Written By: Matt Selman
- Directed By: Mark Kirkland
- Ep: 338
- Sleeping With the Enemy
- Blackboard Line:
- Special Guest Voice: Marcia Wallace
- Also Starring: Pamela Hayden, Tress MacNeille, Russi Taylor, Karl Wiedergott
- Written By: Jon Vitti
- Directed By: Lauren MacMullan
- Ep: 339
- She Used to Be My Girl
- Blackboard Line: POKING A DEAD RACCOON IS NOT RESEARCH
- Special Guest Voice: Kim Cattrall
- Also Starring: Tress MacNeille, Karl Wiedergott
- Written By: Tim Long
- Directed By: Matt Nastuk
- Ep: 340
- Fat Man and Little Boy
- Blackboard Line:
- Special Guest Voice: Eric Idle
- Also Starring: Terry W. Greene, Pamela Hayden, Tress MacNeille, Russi Taylor, Karl Wiedergott
- Written By: Joel H. Cohen
- Directed By: Mike B. Anderson
- Ep: 341
- Midnight Rx
- Blackboard Line:
- Also Starring: Pamela Hayden, Tress MacNeille, Karl Wiedergott
- Written By: Marc Wilmore
- Directed By: Nancy Kruse
- Ep: 342
- Mommie Beerest
- Blackboard Line:
- Also Starring: Tress MacNeille, Karl Wiedergott
- Written By: Michael Price
- Directed By: Mark Kirkland
- Ep: 343
- Homer and Ned's Hail Mary Pass
- Blackboard Line:
- Special Guest Voices: Tom Brady, LeBron James, Michelle Kwan, Yao Ming, Warren Sapp
- Also Starring: Pamela Hayden, Tress MacNeille, Karl Wiedergott
- Written By: Tim Long
- Directed By: Steven Dean Moore
- Ep: 344
- Pranksta Rap
- Blackboard Line:
- Special Guest Voice: 50 Cent
- Also Starring: Dana Gould, Pamela Hayden, Tress MacNeille, Karl Wiedergott
- Written By: Matt Selman
- Directed By: Mike B. Anderson
- Ep: 345
- There's Something About Marrying
- Blackboard Line:
- Special Guest Voice: Marcia Wallace
- Also Starring: Pamela Hayden, Tress MacNeille, Russi Taylor, Karl Wiedergott
- Written By: J. Stewart Burns
- Directed By: Nancy Kruse
- Ep: 346
- On a Clear Day I Can't See My Sister
- Blackboard Line: BEER IN A MILK CARTON IS NOT MILK
- Special Guest Voices: Gary Busey, Jane Kaczmarek, Marcia Wallace
- Also Starring: Pamela Hayden, Tress MacNeille, Russi Taylor, Karl Wiedergott
- Written By: Jeff Westbrook
- Directed By: Bob Anderson
- Ep: 347
- Goo Goo Gai Pan
- Blackboard Line:
- Special Guest Voices: Lucy Liu, Robert Wagner
- Also Starring: Pamela Hayden, Tress MacNeille, Karl Wiedergott
- Written By: Lawrence Talbot
- Directed By: Lance Kramer
- Ep: 348
- Mobile Homer
- Blackboard Line:
- Also Starring: Tress MacNeille, Karl Wiedergott
- Written By: Tim Long
- Directed By: Raymond S. Persi
- Ep: 349
- The Seven-Beer Snitch
- Blackboard Line:
- Special Guest Voices: Frank Gehry, Joe Mantegna, Charles Napier
- Also Starring: Pamela Hayden, Tress MacNeille, Karl Wiedergott
- Written By: Bill Odenkirk
- Directed By: Matthew Nastuk
- Ep: 350
- Future-Drama
- Blackboard Line:
- Special Guest Voice: John DiMaggio, Amy Poehler, Marcia Wallace
- Also Starring: Pamela Hayden, Tress MacNeille, Russi Taylor, Karl Wiedergott
- Written By: Matt Selman
- Directed By: Mike B. Anderson
- Ep: 351
- Don't Fear the Roofer
- Blackboard Line:
- Special Guest Voices: Stephen Hawking, Ray Romano
- Also Starring: Tress MacNeille, Karl Wiedergott
- Written By: Kevin Curran
- Directed By: Mark Kirkland
- Ep: 352
- The Heartbroke Kid
- Blackboard Line:
- Special Guest Voices: A. Brooks, Marcia Wallace
- Also Starring: Pamela Hayden, Tress MacNeille, Russi Taylor, Karl Wiedergott
- Written By: Ian Maxtone-Graham
- Directed By: Steven Dean Moore
- Ep: 353
- A Star is Torn
- Blackboard Line:
- Special Guest Voice: Fantasia Barrino
- Also Starring: Tress MacNeille, Pamela Hayden, Karl Wiedergott
- Written By: Carolyn Omine
- Directed By: Nancy Kruse
- Ep: 354
- Thank God, It's Doomsday
- Blackboard Line:
- Also Starring: Tress MacNeille, Pamela Hayden, Karl Wiedergott
- Special Guest Bands: Baha Men, Los Lobos
- Written By: Don Payne
- Directed By: Michael Marcantel
- Ep: 355
- Home Away From Homer
- Blackboard Line: A BOOGER IS NOT A BOOKMARK
- Special Guest Voice: Jason Bateman
- Also Starring: Pamela Hayden, Tress MacNeille, Karl Wiedergott
- Written By: Joel H. Cohen
- Directed By: Bob Anderson
- Ep: 356
- The Father, the Son and the Holy Guest Star
- Blackboard Line:
- Special Guest Voices: Liam Neeson, Marcia Wallace
- Also Starring: Pamela Hayden, Tress MacNeille, Maggie Roswell, Russi Taylor, Karl Wiedergott
- Written By: Matt Warburton
- Directed By: Michael Polcino
| Dan Castellaneta .......... Homer Simpson / Krusty the Klown |
| Julie Kavner ................. Marge Simpson / Patty & Selma |
| Nancy Cartwright ............... Bart Simpson / Nelson Muntz |
| Yeardley Smith ................................ Lisa Simpson |
| Hank Azaria ............... Apu / Moe Szyslak / Chief Wiggum |
| Harry Shearer .............. Montgomery Burns / Ned Flanders |
