| Voice Cast | | Original Voice Cast |
|---|
| Keye Luke ........................... Charlie Chan | | Stephen Wong .................................... Stanley Chan |
| Cynthia Adler ............................ various | | Virginia Ann Lee .................................. Suzie Chan |
| Gene Andrusco .......................... Flip Chan | | Leslie Juwai ....................................... Mimi Chan |
| Jodie Foster ........................... Anne Chan | | Leslie Kumamota .................................... Anne Chan |
| Lisa Gerritsen ........................... various | | Michael Takamoto .................................... Tom Chan |
| Johnny Gunn ............................. Tom Chan | | Jay Jay Jue ........................................ Flip Chan |
| Bob Ito ............................... Henry Chan | | Debbie Jue ........................................ Nancy Chan |
| Beverly Kushida ....................... Nancy Chan | | Robin Toma ...................................... Scooter Chan |
| Cherylene Lee ............. Suzie Chan / Mimi Chan | | |
| Don Messick .............................. Chu-Chu | | |
| Michael Morgan ...................... Scooter Chan | | (original voices were recast and the show was re-dubbed |
| Hazel Shermet ............................ various | | after the first airing because it was perceived that young |
| Brian Tochi ............................ Alan Chan | | children were having trouble understanding the heavy accents) |
| Janet Waldo .............................. various | | |
| Len Weinrib ......................... Stanley Chan | | |
